Cancer treatments research paper

Inthe surgeon William Halsted [ 18 ] described the surgery that became the standard of care for many years to come, the radical Halsted mastectomy.

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A range of new surgical approaches were developed given the growing body of information on carcinogenesis and metastasis mechanisms and important improvements were made on surgical techniques, such as anaesthesia, surgical gloves and vestments, and disinfection.

Posted: June 14, Researchers have discovered a potential way to turn on one of the most commonly silenced tumor-suppressor proteins in cancer, called PTEN.

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Conventional histological evaluation of breast cancer by pathologists has identified several histological subtypes; however, this morphology-based breast cancer taxonomy is of limited relevance in terms of tailoring treatment strategies for individual patients. Posted: December 1, People with HIV are often excluded from clinical trials to protect their safety. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Axillary dissection was used as part of the surgical treatment of breast cancer by Banks in Liverpool [ 17 ]. Tailoring the surgery method and the adjuvant treatment according to each patient started to be a reality. Believing that the disease had an initial local behaviour with a constant path of dissemination, from the breast to the axillary nodes, and only then to distant locations of the body, Halsted developed a technique that would remove the whole tumour in one piece along with the pectoral muscles, lymphatic vessels, and the axillary lymph nodes [ 18 ]. Posted: March 9, Initial results from a series of three small clinical trials of a targeted cancer therapy called larotrectinib suggest that it may be effective in patients—children and adults—with a wide variety of cancer types. The distinct nature of the breast cancer intrinsic subtypes has been reinforced by studies that coupled gene expression-profiling analysis with gene copy number analysis, indicating that the former ones are associated with recurrent copy number aberrations CNA. Are biosimilars effective and will they expand treatment options for patients? Researchers are now trying to better understand how and why these side effects occur and develop strategies for better managing them. Posted: August 15, A new study conducted primarily in mice suggests that chemotherapy given before surgery for breast cancer can cause changes in cells in and around the tumor that are tied to an increased risk of the cancer spreading to other areas of the body.

Table 1. Posted: August 11, A drug used to treat several blood cancers, ibrutinib, has been approved by FDA to treat chronic graft-versus-host disease, making it the first approved therapy for this potentially fatal side effect of cancer-related stem cell transplants.

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The concept of sentinel lymph node dissection to avoid full axillary dissection was also investigated in this context. Posted: May 10, Cancer patients, even those who are undergoing difficult treatments, are willing to devote time to completing thorough assessments of the side effects they encounter in clinical trials, a new study finds.

Cancer treatments research paper

Posted: May 21, New findings from a clinical trial suggest that a single dose of radiation therapy may control painful bone metastases as effectively as multiple lower doses of radiation therapy. As has happened in the past, we are coming to a moment where different approaches to breast cancer treatment need to be developed. Posted: July 29, Injecting cells undergoing necroptosis, a form of cell death, into tumors in mice kickstarted an immune response against the tumors, researchers have found. Nevertheless, individual characteristics that could play a role in the selected patient remain an open area of research. Researchers are now trying to better understand how and why these side effects occur and develop strategies for better managing them. Of note, in both cases, a true personalisation is yet to be achieved; it is more accurate to refer to stratified cancer medicine, given that for individual patients with hormone receptor positive or HER2-positive breast cancer treated with endocrine treatment or HER2 blockade, respectively, therapeutic resistance can occur. Posted: May 10, Cancer patients, even those who are undergoing difficult treatments, are willing to devote time to completing thorough assessments of the side effects they encounter in clinical trials, a new study finds. This less aggressive approach was proved to be as effective as the more radical and mutilating Halsted method [ 28 ]. Accurate translations of the medical manuscripts and the establishment of the early medical schools allowed the continuation of medical development [ 7 ]. The development of chemotherapy also happened in the second half of the 20th century; first with the mustard gas derivatives [ 22 ], followed by a rapid expansion in the chemotherapy portfolio after the heavy financing of cancer drug research established by the US National Cancer Act of [ 23 ]. The findings were published in Nature Medicine.

The improvement of surgical and medical sciences occurred in the context of the age of enlightenment. Posted: November 8, Research studies show tests that analyze tumor DNA in blood, called liquid biopsies, may help detect cancer early, guide precision cancer treatment, and track treatment response.

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The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials.

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Cancer Treatment and Research Communications